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 Post subject: propranolol
PostPosted: Wed Jul 04, 2007 4:24 am 
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Nothing new, but interesting nonetheless.

http://60minutes.yahoo.com/segment/21/memory_drug
http://www.harvardmagazine.com/on-line/070467.html
http://www.popsci.com/popsci/medicine/7 ... drcrd.html

It seems it would be very helpful for ptsd patients.
But I was extremely creeped out by this medication.
Painful memories were there, but I was unable to attach emotions to them.
Sweet memories were there, but again, I was unable to stream them.
I felt a sense of euphoria as the medication wore off.
For about a week, I couldn't shake that eerie feeling that maybe one pill had altered my memories, or maybe I was just paranoid.
Nor do I remember much about that day I had forgotten.

So even if you do suffer from severe trauma... proceed with caution.
What is a life without the sour and the sweet?
But yea, I thought anti-depressants were bad.


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PostPosted: Thu Jul 05, 2007 3:14 pm 
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Wow... hell no. I can imagine that would have some negative consequences.

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PostPosted: Thu Jul 05, 2007 3:25 pm 
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I think a long term and social effect is making minds less tolerable to high-stress situations. I can't fathom where I would be now if I didn't experience extreme pain and traumatic events. It shapes character, makes one wiser.

The fact that it blocks hormones from the amygdala is frightening. The amygdala helps us respond to impending danger. For example, when you flinch because you saw a garden hose that looked like a copperhead, that's the amygdala working. We learn from pain, even the excruciating and mentally traumatizing type. It's the brain's way of saying, "Don't do whatever you did that put yourself in that much danger ever again."

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PostPosted: Fri Jul 06, 2007 6:43 pm 
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I have a relative who is taking this medication for panic attacks. It's not currently being prescribed for anxiety because it's still experimental, but she demanded it. She actually really likes it because there are absolutely no side effects or feelings of intoxication. You just feel free of any bad memories that may be hindering you from life. There's no past or future to be concerned of. I notice she often complains of short term memory - the kind a pot smoker would have - and finds herself making to do lists. I told her that's not right. She's not 65 yet! But she seems indifferent to not only my concerns, but her own as well.

The price for having peace of mind...


Last edited by Izu on Thu Sep 27, 2007 2:00 am, edited 1 time in total.

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PostPosted: Sat Jul 07, 2007 3:30 pm 
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Dom wrote:
I think a long term and social effect is making minds less tolerable to high-stress situations.


What did people do before psychotropic medications were available to them? Are most people (not all) becoming dependent on these types of medications to solve their problems?

I think people (myself included) create their own problems. I never can tell if people feel comforted by the hole they're in or if they just don't know how to climb out of it. If people just stopped worrying about the things they didn't have and said 'Enough is enough'... maybe drug companies would have to start a new ad campaign. But I guess nothing is that simple.

I know that I may be ignorant about brain chemistry and mental illnesses - but life is too short. And hearing myself and my friends talk about everything that bothers them makes me think, 'For what?' I know sleeping takes up 1/3 of our life, but I would like to know how much worrying consumes. Life is happening right now... I often forget that.


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PostPosted: Sun Sep 23, 2007 11:49 pm 
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it's a beta-blocker. used to lower blood pressure, and supress the fight-or-flight response. I just ordered some inderals not too long ago, good stress killer (and stress does kill you) without the withdrawal like benzos.
psychonauts used to take them to quell body load from phenethylamines like mescaline and lucky 7.

it's an old-school anxiolytic, tried and true since the late 50's. yep, certainly not new or profound; one that is fairly profound is tianeptine.... it acts in a counterintuitive way to most antidepressants...by enhancing serotonin reuptake.


and to answer your question... people meditated. dependency depends on whether or not your body really needs it, not whether or not your mind thinks it does (not to say that your mind can't perpetuate its own demise)

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PostPosted: Mon Sep 24, 2007 10:05 am 
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I keep reading the title as "propane! lol"


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PostPosted: Mon Sep 24, 2007 10:15 am 
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Leslie 2.0 v2 wrote:
I keep reading the title as "propane! lol"
Or "Propa, no lol!" Either way, there was no actual "lol'ing'".

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PostPosted: Mon Sep 24, 2007 10:17 am 
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certainly no "lol"ling with this stuff. it's more of an "ehh."

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PostPosted: Tue Sep 25, 2007 5:05 am 
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polymer wrote:
it's a beta-blocker. used to lower blood pressure, and supress the fight-or-flight response. I just ordered some inderals not too long ago, good stress killer (and stress does kill you) without the withdrawal like benzos.
psychonauts used to take them to quell body load from phenethylamines like mescaline and lucky 7.

it's an old-school anxiolytic, tried and true since the late 50's. yep, certainly not new or profound; one that is fairly profound is tianeptine.... it acts in a counterintuitive way to most antidepressants...by enhancing serotonin reuptake.

and to answer your question... people meditated. dependency depends on whether or not your body really needs it, not whether or not your mind thinks it does (not to say that your mind can't perpetuate its own demise)


Very interesting.

But what is body load?


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PostPosted: Tue Sep 25, 2007 1:58 pm 
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somatic side effects inherent to phenethylamine use, typically characterized by nausea and tremors.

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PostPosted: Wed Sep 26, 2007 8:49 pm 
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Personally, I think the pill is a breakthrough in helping patients with severe problems overcome some of the major difficulties in their lives. I have met people who suffer from ptsd and rape victims who have had severe problems functioning in daily life because of previous memories haunting them from day to day. Though there is an ethical concern, I think that most people shouldnt rely heavily on medication to fix their problems. I would suggest therapy, or therapy AND medication combined [since therapy helps regulate medication use]. The phrase, "going to therapy," has always had always a negative connotation in today's society because most people think that therapy is for "crazies," when in doubt, it is very beneficial for anyone who decides to have their problems addressed in a healthy manner. Now, I am not saying that therapy works for anyone, but it is helpful to get the issue out and build on from there. Anyhow, to a normal person, the thought of a pill that helps erase memories is scary, but to those who really suffer from such illnesses such as ptsd, rape, etc, it comes as a relief.











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PostPosted: Wed Sep 26, 2007 10:53 pm 
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I don't think inderal actually erases memories, per se.. it merely disconnects anxieties associated with them. This med typically voids emotions connected with stressful stimuli by blocking beta epinephrine at the receptors. Perceived stress from a memory or event automatically triggers sympathetic CNS response, propranolol blocks it.

It's the classic chill pill, like I said, it's old-school.

http://en.wikipedia.org/wiki/Propranolol


I definitely prefer it over valium (if I wanted a stupor, I'd just drink some guinness). I keep a stash of Indies for pre-exam anxiety, and speech delivery; it's probably less toxic than tylenol. excellent for stage-fright too.

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PostPosted: Thu Sep 27, 2007 1:58 am 
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djfaulk05 wrote:
Personally, I think the pill is a breakthrough in helping patients with severe problems overcome some of the major difficulties in their lives. I have met people who suffer from ptsd and rape victims who have had severe problems functioning in daily life because of previous memories haunting them from day to day. Though there is an ethical concern, I think that most people shouldnt rely heavily on medication to fix their problems. I would suggest therapy, or therapy AND medication combined [since therapy helps regulate medication use]. The phrase, "going to therapy," has always had always a negative connotation in today's society because most people think that therapy is for "crazies," when in doubt, it is very beneficial for anyone who decides to have their problems addressed in a healthy manner. Now, I am not saying that therapy works for anyone, but it is helpful to get the issue out and build on from there. Anyhow, to a normal person, the thought of a pill that helps erase memories is scary, but to those who really suffer from such illnesses such as ptsd, rape, etc, it comes as a relief.


I'm coming around to the use of psychotropic medications. I've just been bothered by the fact that because these medications are prescribed by physicians, and not psychiatrists 85% of the time, they are often times not combined with therapy. If the medications are used as a tool to face one's problems, as psychonauts do with psychedelics, then they will be extremely beneficial. However, the unethical use of anti-anxiety or anti-depressants is using it TO disconnect one from their painful memories, thus burying the problems further into the subconsious mind to be left undealt with. I worry this just makes the problem worse, not better. I understand some people's burdens can become too overwhelming to cope with but therapy and medicinal purposes should be about resolving the problem not covering it up. People are to learn and grow from their mistakes, not shove them to the side to be forgotten about. It would be nice if people weren't so reliant on prescription medications to solve their worries because there are other ways to deal with emotional turmoil. Looking inside one's self to change can be very helpful, along with keeping a journal and becoming consiously aware of how certain situations may bring about negative emotions. Humans have the power to adapt, and rise above their circumstances, and change - or one is just a victim. Afterall, when one hits rock bottom, the only person that can help a person out of the hole is themself because no friend, therapist, or anti-depressant knows one better than themself.


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PostPosted: Thu Sep 27, 2007 9:57 am 
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i really really just wanted to type propranoLOL.

propranolololol

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PostPosted: Thu Sep 27, 2007 11:48 am 
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Izu wrote:
djfaulk05 wrote:
Personally, I think the pill is a breakthrough in helping patients with severe problems overcome some of the major difficulties in their lives. I have met people who suffer from ptsd and rape victims who have had severe problems functioning in daily life because of previous memories haunting them from day to day. Though there is an ethical concern, I think that most people shouldnt rely heavily on medication to fix their problems. I would suggest therapy, or therapy AND medication combined [since therapy helps regulate medication use]. The phrase, "going to therapy," has always had always a negative connotation in today's society because most people think that therapy is for "crazies," when in doubt, it is very beneficial for anyone who decides to have their problems addressed in a healthy manner. Now, I am not saying that therapy works for anyone, but it is helpful to get the issue out and build on from there. Anyhow, to a normal person, the thought of a pill that helps erase memories is scary, but to those who really suffer from such illnesses such as ptsd, rape, etc, it comes as a relief.


I'm coming around to the use of psychotropic medications. I've just been bothered by the fact that because these medications are prescribed by physicians, and not psychiatrists 85% of the time, they are often times not combined with therapy. If the medications are used as a tool to face one's problems, as psychonauts do with psychedelics, then they will be extremely beneficial. However, the unethical use of anti-anxiety or anti-depressants is using it TO disconnect one from their painful memories, thus burying the problems further into the subconsious mind to be left undealt with. I worry this just makes the problem worse, not better. I understand some people's burdens can become too overwhelming to cope with but therapy and medicinal purposes should be about resolving the problem not covering it up. People are to learn and grow from their mistakes, not shove them to the side to be forgotten about. It would be nice if people weren't so reliant on prescription medications to solve their worries because there are other ways to deal with emotional turmoil. Looking inside one's self to change can be very helpful, along with keeping a journal and becoming consiously aware of how certain situations may bring about negative emotions. Humans have the power to adapt, and rise above their circumstances, and change - or one is just a victim. Afterall, when one hits rock bottom, the only person that can help a person out of the hole is themself because no friend, therapist, or anti-depressant knows one better than themself.


you're preaching to the choir, son. And while I share similar sentiments about the status quo, you have to realize that diagnosing, and matching the meds to fit the diagnosis, is big business. And that's what westerners understand...business, and quick fixes...convenience. it's alot harder to take the time to meditate, which is similar to working out. it puts the mind at ease, but requires more work. but like weight loss, people would rather pop a pill than devote the time necessary to really address the problem. and for some issues, like severe tics (tourettes), acute schizophrenia....unfortunately, meditation won't address those; they require more rigorous therapy. but for common depression, and life's daily stressors... a deep meditation can work wonders.
some people pray, which is pretty much going through the motions and asking a higher power for something. actually taking initiative upon yourself to put your mind at ease is much more effective.

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PostPosted: Thu Sep 27, 2007 12:01 pm 
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shane wrote:
i really really just wanted to type propranoLOL.

propranolololol


pindolollerskater

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PostPosted: Thu Sep 27, 2007 12:18 pm 
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There are obviously some substances that can help wounds heal faster. Just like there are substances that can help or assist in maintaining a fit physique or help build muscle or help keep you healthy. You'd think the same concept could be applied to "mental illnesses". Except the problem with most psychotropic drugs is that they're so extreme in their effects it's like taking an axe to a mosquito bite.

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PostPosted: Thu Sep 27, 2007 12:27 pm 
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aside from that, everyone has different genetic makeups, thus different body chem. an example of this is tolerance to certain analgesics and some antidepressants; if a person is lacking a sufficient concentration of CYP2D6, downing 20 oxycontins won't do any good.

the other pharm dilemma is rebound effect. dopamine antagonists and SSRIs are notorious for this. quitting cold turkey after an extended period of administration can be hellish. weaning someone off a drug can take a while.

needless to say, it probably wouldn't be in one's best interest to take a regimin of pills to offset various side-effects/address certain benign tics, when one isn't suffering from an acute mental illness. just, get a hobby.


as for propranolol, the stuff is tame. rarely use it, but it's good to have some on tap for a moment's notice.

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PostPosted: Thu Sep 27, 2007 1:14 pm 
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polymer wrote:
aside from that, everyone has different genetic makeups, thus different body chem. an example of this is tolerance to certain analgesics and some antidepressants; if a person is lacking a sufficient concentration of CYP2D6, downing 20 oxycontins won't do any good.

the other pharm dilemma is rebound effect. dopamine antagonists and SSRIs are notorious for this. quitting cold turkey after an extended period of administration can be hellish. weaning someone off a drug can take a while.


So do antidepressants deprive the body of producing dopamine and serotonin in the same way heroin deprives the production of natural opiates?

And what is CYP2D6 and analgesics?

BTW, this is Ash, Aaron's girlfriend. I didn't know it was you. See you Sat.


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PostPosted: Thu Sep 27, 2007 4:56 pm 
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polymer Posted: Thu Sep 27, 2007 9:48 am Post subject:

quote:
Originally posted by Izu:
quote:
--------------------------------------------------------------------------------
Originally posted by djfaulk05: Personally, I think the pill is a breakthrough in helping patients with severe problems overcome some of the major difficulties in their lives. I have met people who suffer from ptsd and rape victims who have had severe problems functioning in daily life because of previous memories haunting them from day to day. Though there is an ethical concern, I think that most people shouldnt rely heavily on medication to fix their problems. I would suggest therapy, or therapy AND medication combined [since therapy helps regulate medication use]. The phrase, "going to therapy," has always had always a negative connotation in today's society because most people think that therapy is for "crazies," when in doubt, it is very beneficial for anyone who decides to have their problems addressed in a healthy manner. Now, I am not saying that therapy works for anyone, but it is helpful to get the issue out and build on from there. Anyhow, to a normal person, the thought of a pill that helps erase memories is scary, but to those who really suffer from such illnesses such as ptsd, rape, etc, it comes as a relief.

--------------------------------------------------------------------------------



I'm coming around to the use of psychotropic medications. I've just been bothered by the fact that because these medications are prescribed by physicians, and not psychiatrists 85% of the time, they are often times not combined with therapy. If the medications are used as a tool to face one's problems, as psychonauts do with psychedelics, then they will be extremely beneficial. However, the unethical use of anti-anxiety or anti-depressants is using it TO disconnect one from their painful memories, thus burying the problems further into the subconsious mind to be left undealt with. I worry this just makes the problem worse, not better. I understand some people's burdens can become too overwhelming to cope with but therapy and medicinal purposes should be about resolving the problem not covering it up. People are to learn and grow from their mistakes, not shove them to the side to be forgotten about. It would be nice if people weren't so reliant on prescription medications to solve their worries because there are other ways to deal with emotional turmoil. Looking inside one's self to change can be very helpful, along with keeping a journal and becoming consiously aware of how certain situations may bring about negative emotions. Humans have the power to adapt, and rise above their circumstances, and change - or one is just a victim. Afterall, when one hits rock bottom, the only person that can help a person out of the hole is themself because no friend, therapist, or anti-depressant knows one better than themself.
--------------------------------------------------------------------------------



you're preaching to the choir, son. And while I share similar sentiments about the status quo, you have to realize that diagnosing, and matching the meds to fit the diagnosis, is big business. And that's what westerners understand...business, and quick fixes...convenience. it's alot harder to take the time to meditate, which is similar to working out. it puts the mind at ease, but requires more work. but like weight loss, people would rather pop a pill than devote the time necessary to really address the problem. and for some issues, like severe tics (tourettes), acute schizophrenia....unfortunately, meditation won't address those; they require more rigorous therapy. but for common depression, and life's daily stressors... a deep meditation can work wonders.
some people pray, which is pretty much going through the motions and asking a higher power for something. actually taking initiative upon yourself to put your mind at ease is much more effective.





I see your point about the meditation thing, but for some people that isnt enough, and/or it doesnt work for them. For someone to find out, later along in their life, that they suffer from some type of illess, or accepting it, is a big "oh no, what do I do now," type of feeling. Yes, though there are extreme cases and normal cases--such as daily stressors, it is still a good idea to get help WHEN needed. I dont doubt that a person can overcome their own problems by their own tactics, but there are those who dont know a thing about coping with stress, anxiety, ocd..etc [just as examples]. People have so many resources available to them, yet the irony is that they dont know about it, embarrassment, or dont do it at all. Accepting that you have a problem, whether it be drug use, psychological problems, or just dealing with daily life, is the first step to overcoming the situation, and my debate here is that, therapy or counceling can help the healing process [though I understand that its not for everyone], and if needed, with medication.


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PostPosted: Thu Sep 27, 2007 5:33 pm 
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Izu wrote:
polymer wrote:
aside from that, everyone has different genetic makeups, thus different body chem. an example of this is tolerance to certain analgesics and some antidepressants; if a person is lacking a sufficient concentration of CYP2D6, downing 20 oxycontins won't do any good.

the other pharm dilemma is rebound effect. dopamine antagonists and SSRIs are notorious for this. quitting cold turkey after an extended period of administration can be hellish. weaning someone off a drug can take a while.


So do antidepressants deprive the body of producing dopamine and serotonin in the same way heroin deprives the production of natural opiates?

And what is CYP2D6 and analgesics?

BTW, this is Ash, Aaron's girlfriend. I didn't know it was you. See you Sat.

oh hi :D
didn't know it was you either. hope you and aaron are down for digital showcase, if you're not too tired.

and to answer your question... not exactly..
some antidepressants block the reuptake transporters (in the case of SSRIs), thus preserving your natural serotonin levels. MAOIs prevent the metabolism of catecholamines (dopamine/norepinephrine), other neurotransmitters responsible for mood. When you abruptly stop taking these meds, your brain rebounds, a sort of metaphorical withdrawal.

CYP2D6 is an enzyme in the liver that catabolyzes a wide variety of drugs, from the thread title, to zoloft, to opiates like dextromethorphan and morphine. when the gene responsible for CYP2D6 expression is lacking, high tolerance to certain drugs is the result.
and analgesic is just another term for painkiller.

so you have inderals? how do they make you feel? they just mellow me out. with tramadol (non-opiate opioid), it's really chill.

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